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Symbol
Name
ID

Sirt1
sirtuin 1
MGI:2135607

Phenotype annotations related to reproductive system

*	Aspects of the system are reported to show a normal phenotype.
!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Mouse Phenotypes

reproductive system phenotype

abnormal sperm flagellum morphology

oligozoospermia

teratozoospermia

globozoospermia

abnormal spermatid morphology

abnormal spermatocyte morphology

multinucleated giant male germ cells

arrest of male meiosis

increased male germ cell apoptosis

immotile sperm

abnormal mammary gland growth during pregnancy

absent corpus luteum

small ovary

abnormal seminiferous tubule morphology

abnormal seminiferous tubule epithelium morphology

small seminiferous tubules

abnormal Sertoli cell development

abnormal adult Leydig cell differentiation

decreased Leydig cell number

decreased testis weight

decreased testes secretion

thin uterus

arrest of spermatogenesis

anovulation

abnormal estrous cycle

absent estrous cycle

female infertility

reduced female fertility

male infertility

reduced male fertility

Availability

Mouse Genotype

Sirt1^tm1.1Ygu/Sirt1^tm1.1Ygu

*

Sirt1^tm1Fwa/Sirt1^tm1Fwa

Sirt1^tm1Mcby/Sirt1^tm1Mcby

*

!

Sirt1^tm3.1Mcby/Sirt1^tm3.1Mcby

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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